| CAS
NO. |
50-71-5
(base), 2244-11-3 (monohydrate) |
|
| EINECS NO. |
200-062-0 |
| FORMULA |
C4H2N2O4·H2O |
| MOL
WT. |
160.08 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
2,4,5,6-Pyrimidintetron; Alloxane monohydrate; |
|
2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate; 2,4,5,6-Tetraoxohexahydropyrimidine
hydrate; 2,4,5,6(1H,3H)-Pyrimidinetetrone, monohydrate; 5-Oxobarbituric
acid monohydrate; Mesoxalylcarbamide monohydrate; Mesoxalylurea
monohydrate; 5,6-Dioxyuracil monohydrate; |
| DERIVATION |
|
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white powder |
| MELTING POINT |
255
C (Decomposes) |
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
|
| pH |
|
| VAPOR DENSITY |
|
| AUTOIGNITION |
|
| NFPA RATINGS |
|
| REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
Allantoin, the
diureide of glyoxylic acid, is a crystallizable oxidation product of uric acid
found in allantoic and amniotic fluids, in fetal urine and in many plants.
(Ureide is a compound derived from urea and contains acid radicles. Those from
one molecule of urea, as alloxan, are monoureides; those derived from two, as
uric acid, are diureides). Allantoin is an urinary excretion product of purine
metabolism in most mammals but not in higher apes including humans. It is
produced synthetically by the oxidation of uric acid. Allantoin is active in
skin-softening (keratolytic effect) and rapid cell regeneration by precipitating
proteins on skin. It is used as an abrasive and astringent agent in the end
products include cosmetic lotions, creams, suntan products, scalp preparations,
shampoos , lipsticks and and various aerosol preparations. It is used in topical
pharmaceutical preparations. Allantoin has been used in various oral hygeine
preparations such as toothpaste and mouthwash as well as in eye drops to treat
watering eyes and in ear drops to clean the ear canal. Alloxan
is an oxidized product of uric acid by nitric acid. When administered to experimental animals,
it produces selective destruction of the beta
cells of the pancreas, causing hyperglycemia and ketoacidosis. Alloxan,
a strong oxidizing
agent, and its reduced product dialuric acid form alloxantin (a hemiacetal)
which is used as a raw material to produce ammonium purpurate dye,
murexide (C8H5N5O6·NH3)
with heating at 100 C in ammonia gas. Murexide is used as a
complexometric titration indicator and as a colorimetric reagent for measurement of calcium and
rare earth metals.
|
Product
|
CAS
RN.
|
| Alloxan |
50-71-5 |
| Alloxantin |
76-24-4 |
| Violuric acid |
87-39-8 |
| Alloxanic acid |
470-44-0 |
| Violuric acid
monosodium salt
|
825-29-6
|
| Alloxan
monohydrate |
2244-11-3 |
| Oxypurinol |
2465-59-0 |
| 1,3-Dimethylalloxan |
2757-85-9 |
| 2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate |
3237-50-1 |
| Alloxanthin |
28380-31-6 |
|
5-((4-Methoxy-2-nitrophenyl)hydrazone) alloxan |
31353-87-4 |
| 1-Phenylvioluric acid |
82628-28-2 |
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white crystalline
powder |
|
ASSAY
|
98.5%
min |
|
MELTING
POINT
|
255
C
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER INFORMATION |
|
Hazard
Symbols: XN, Risk Phrases: 20/21/22, Safety Phrases:
36 |